Next-Generation AlphaFold
DeepMind previews the next AlphaFold with dramatically expanded scope of biomolecular complexes.
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Multi-entity complexes: Jointly predicts structure of complexes including proteins, nucleic acids, small molecules, ions, and modified residues in a single unified model.
Beyond protein-only: Dramatically expands applicability beyond AlphaFold 2's protein-only regime, opening up drug discovery and RNA biology workflows.
Beats specialist predictors: Achieves greater accuracy on protein-nucleic acid interactions than specialized predictors in that domain - remarkable for a general model.
Biology pipeline signal: Preview of the capability direction that would crystallize as AlphaFold 3 in 2024, with profound implications for structural biology research.