AlphaMissense

71M variants classified: Categorizes 89% of all 71 million possible missense variants as either likely pathogenic or likely benign, producing a comprehensive human-genome catalog.

Disease-cause identification: Helps pinpoint the molecular cause of genetic diseases, where missense variant interpretation is a known bottleneck in clinical genetics.

AlphaFold lineage: Builds on the AlphaFold family's protein-structure understanding, leveraging structural context to assess variant impact.

Open catalog: The full catalog is released to accelerate research in rare-disease diagnosis and drug target discovery.